Long-term Resveratrol Administration Reduces Renal Oxidative Stress and Apoptosis Rate In Experimental Model of Type 2 Diabetes

The present study was designed to evaluate whether long-term resveratrol administration has beneficial effects on renal oxidative stress and apoptosis rate in diabetic rats. Male Wistar rats were divided into four groups (n=6): normal control, diabetic control, normal rats treated with resveratrol, and diabetic rats treated with resveratrol. Diabetes was induced by injection of streptozotocin (50 mg/kg; i.p.), 15 min after the prescription of nicotinamide (110 mg/kg; i.p.) in 12 h fasted rats. RESULTS: Four-month oral resveratrol prescriptions (5 mg/kg/day) significantly attenuated the enhancement of blood glucose, glycosylated hemoglobin, urea, and creatinine and 8isoprostane levels in diabetic rats. Moreover, resveratrol administration to diabetic rats improved the reduced levels of glutathione, total antioxidant capacity and the antioxidant enzymes activities (superoxide dismutase, glutathione peroxidase and catalase). The apoptosis rate significantly increased in the renal of diabetic groups as compared with normal groups. Treatment with resveratrol reduced this enhancement statistically. These results suggest that chronic resveratrol administration is safe and effective and also may be considered as a therapeutic compound in diabetes. [Saeed Khamneh, Farhad Ghadiri Soufi, Fatemeh Afshar. Long-term Resveratrol Administration Reduces Renal Oxidative Stress and Apoptosis Rate In Experimental Model of Type 2 Diabetes. Life Sci J 2012;9(4):29973001]. (ISSN: 1097-8135). http://www.lifesciencesite.com. 440